Synthesis and anti-histaminic activity of some novel pyrimidines.
نویسندگان
چکیده
Novel pyrimidines were prepared by the condensation of chalcones of 4'-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1-5 were assigned on the basis of elemental analysis, IR, (1)H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.
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ورودعنوان ژورنال:
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
دوره 17 3 شماره
صفحات -
تاریخ انتشار 2009